We study the structure, function and destruction of cyclin-dependent protein kinases (CDKs), which control cell cycle transitions: the initiation of chromosome replication, the onset of mitosis and the return to interphase at the end of cell division. We are particularly interested in the role of cyclins in the activation of CDK1 and CDK2, and are trying to understand how particular cyclins control particular processes.
More details here.

- Identifying substrates of mitotic kinases using "Shokat" strategy.

WP6

Tim Hunt
Cell Cycle Control Laboratory
London Research Institute
Clare Hall Laboratories
Blanche Lane
South Mimms
Herts EN6 3LD
United Kingdom

Email: tim.hunt@cancer.org.uk