The focus of our research is to investigate cell cycle regulation of the DNA replication licensing pathway and mitosis in human cells and to determine how these critical steps in growth control become dysregulated in cancer. Diagnostic leads arising from these studies are being taken forward in multi-centre clinical trials. The assembly of the DNA replication initiation complex and crosstalk between the licensing machinery and checkpoint pathways are being studied to provide strategies for therapeutic intervention.
More details here.

To investigate the role of novel mitotic regulators in the pathogenesis of human tumours and whether dysregulation of these regulatory proteins contributes to generation of genomic instability in aggressive aneuploid cancers.

WP8

Kai Stoeber
University College London
Wolfson Institute for Biomedical Research
The Cruciform Building
Gower Street
London WC1E 6BT
United Kingdom

Email: k.stoeber@ucl.ac.uk