Our laboratory is interested in understanding the inner workings of the spindle assembly checkpoint and its interaction with kinetochores during the cell cycle. We use a combination of methods ranging from crystallography, to biochemistry and cell biology to gain an understanding of the molecular bases of the recruitment of the spindle checkpoint components to the kinetochores, of their role in the generation of a signal that halts anaphase.
More details here.

- Analyzing the structure of mitotic kinases.

- Generating inhibitor-resistant kinases.

WP6

Andrea Musacchio
Dept. of Experimental Oncology
European Institute of Oncology
Via Adamello 16
I-20139 Milan
Italy

Email: andrea.musacchio@ifom-ieo-campus.it